The airline said: “Due to another French Air Traffic Control strike, we have regrettably been forced to cancel approximately 130 flights to and from France on Thursday June 29.
“All affected passengers have been notified via email and SMS with all the information you need to change your flight or request a refund.
“We advise all passengers travelling to or from France to monitor the Ryanair app/website for the most up to date information regarding your flight.”
French air traffic control staff are striking over the country’s pension reforms and this is the 60th day of strikes this year.
Ryanair has urged British travellers to sign a petition to keep “European Skies Open” during strike action.
The budget airline said that staff from other countries should be able to step up to keep flights operating.
It claimed it had been forced to cancel over 4,000 flights due to air traffic control strikes in France this year alone.
Flights travelling over France’s airspace could also be affected by the strikes leading to widespread cancellations.
Ryanair’s petition so far has over a million signatures and the airline is calling on the EU Commission to change minimum service rules.
The low-cost carrier said it apologised for the cancellations and delays which it said was “entirely outside of Ryanair’s control”.
British tourists travelling from Heathrow this summer recently got good news when security staff called off 30 days of planned action.
The Unite union which represents the security staff said workers had voted to accept a new pay offer.
Airlines aren’t usually required to offer passengers compensation if flights are cancelled due to an external strike.